Cancer is caused by a series of genomic changes leading directly or indirectly to
disturbance of growth, differentiation and tissue integrity. Genomic, transcriptional or …

Address correspondence to: Dr DR Welch, The Jake Gittlen Cancer Research Institute
(C7810), Penn State University College of Medicine, 500 University Drive, Hershey, PA …

Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous
melanomas generally lack evidence of significant necrosis and contain patterned networks …

Tumor cells display progressive changes in metabolism that correlate with malignancy,
including development of a lipogenic phenotype. How stored fats are liberated and …

Background Microcell-mediated transfer of chromosome 6 into human C8161 and MelJuSo
melanoma cells suppresses their ability to metastasize by at least 95% without affecting their …

Abstract Phage displaying an Arg-Gly-Asp (RGD)-containing peptide with a high affinity for
αv integrins homed to tumors when injected intravenously into tumor-bearing mice. A …

Studies suggest that stress can be a co-factor for the initiation and progression of cancer.
The catecholamine stress hormone, norepinephrine (NE), may influence tumor progression …

Bidirectional cellular communication is integral to both cancer progression and
embryological development. In addition, aggressive tumor cells are phenotypically plastic …

Purpose: Autophagy consists of lysosome-dependent degradation of cytoplasmic contents
sequestered by autophagic vesicles (AV). The role of autophagy in determining tumor …

Certain aggressive melanoma cell lines exhibit a dedifferentiated phenotype, expressing
genes that are characteristic of various cell types including endothelial, neural, and stem …