Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

The conserved yeast E3 ubiquitin ligase Bre1 and its partner, the E2 ubiquitin-conjugating
enzyme Rad6, monoubiquitinate histone H2B across gene bodies during the transcription …

Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …

From bacteria to humans, individual cells within isogenic populations can show significant
variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate …

Ribosome biogenesis requires prodigious transcriptional output in rapidly growing yeast
cells and is highly regulated in response to both growth and stress signals. This minireview …

Gene transcription is a highly regulated process in all animals. In Drosophila, two major
transcriptional programs, housekee** and developmental, have promoters with distinct …

Although we have made significant progress, we still possess a limited understanding of
how genomic and epigenomic information directs gene expression programs through …