Preparation and bioactivity of the rare ginsenosides Rg3 and Rh2: An updated review

W Xu, W Lyu, C Duan, F Ma, X Li, D Li - Fitoterapia, 2023 - Elsevier
Ginseng, an ancient medicinal herb, is used in oriental medicine for the treatment of various
diseases. Saponins are the main bioactive components of ginseng, but the multiple glucosyl …

Future of PD-1/PD-L1 axis modulation for the treatment of triple-negative breast cancer

M Nakhjavani, S Shigdar - Pharmacological research, 2022 - Elsevier
Triple-negative breast cancer (TNBC) has the worst prognosis among the subtypes of breast
cancer, with no targeted therapy available. Immunotherapy targeting programmed cell death …

Ginsenosides: changing the basic hallmarks of cancer cells to achieve the purpose of treating breast cancer

R Jiang, Z Fang, H Zhang, J Xu, J Zhu, K Chen… - Chinese Medicine, 2023 - Springer
In 2021, breast cancer accounted for a substantial proportion of cancer cases and
represented the second leading cause of cancer deaths among women worldwide. Although …

Triple-negative breast cancer brain metastasis: An update on druggable targets, current clinical trials, and future treatment options

M Nakhjavani, RM Samarasinghe, S Shigdar - Drug Discovery Today, 2022 - Elsevier
Highlights•Treatment of brain metastasis is very challenging, due to the role of blood–brain
barrier.•Triple-negative breast cancer (TNBC) lacks targeted therapy and is challenging to …

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

M Fan, M Shan, X Lan, X Fang, D Song… - Frontiers in …, 2022 - frontiersin.org
Breast cancer (BC) is one of the most common malignant tumor, the incidence of which has
increased worldwide in recent years. Ginsenosides are the main active components of …

Natural blockers of PD-1/PD-L1 interaction for the immunotherapy of triple-negative breast cancer-brain metastasis

M Nakhjavani, S Shigdar - Cancers, 2022 - mdpi.com
Simple Summary Aggressive types of breast cancer spread to the brain and can form a new
tumor there. The treatment of such a tumor is more difficult because there is a membrane …

[HTML][HTML] Enhancement of Doxorubicin Efficacy by Bacopaside II in Triple-Negative Breast Cancer Cells

SK Rad, KKL Yeo, R Li, F Wu, S Liu… - Biomolecules, 2025 - mdpi.com
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with limited
treatment options and high resistance to chemotherapy. Doxorubicin is commonly used, but …

Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects-A Review

AI Tanko, S Hosawi, E Moglad, M Afzal… - Current Medicinal …, 2025 - benthamdirect.com
Cancer is one of the most devastating illnesses in the world, impacting millions of individuals
every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy …

Growth inhibitory efficacy of Chinese herbs in a cellular model for triple-negative breast cancer

NT Telang, HB Nair, GYC Wong - Pharmaceuticals, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor-
α progesterone receptor and human epidermal growth factor receptor-2. Treatment for this …

Intelligent Pharmacy

Y Wang, G Li, T Chen, W Wu, Z Yan, X Li - journal.hep.com.cn
ABSTRACT Ginsenoside Rg3 (Rg3), extracted from the root of Panax ginseng, is one of the
most abundant ginsenosides. Rg3 exhibits anticancer activity in various cancer models in …