Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

The signal transducer and activator of transcription 3 (STAT3) protein is a major transcription
factor involved in many cellular processes, such as cell growth and proliferation …

Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD)
treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based …

Non-coding RNAs (ncRNA) have paved the way to new perspectives on the regulation of
gene expression, not only in biology and medicine, but also in associated fields and …

Abstract T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type
protein tyrosine phosphatase that is ubiquitously expressed in human cells. TCPTP is a …

Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2,
cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other …

The T-cell protein tyrosine phosphatase (TCPTP/PTPN2) targets a broad variety of
substrates across different subcellular compartments. In spite of that, the structural basis for …

Diabetic kidney disease (DKD) has become a key cause of end-stage renal disease
worldwide. Inflammation and fibrosis have been shown to play important roles in the …

Loss-of-function variants of protein tyrosine phosphatase non-receptor type 2 (PTPN2)
enhance risk of inflammatory bowel disease and rheumatoid arthritis; however, whether the …

Goblet cell loss, which leads to the reduction of mucin secretion, is a hallmark of ulcerative
colitis (UC). We previously reported that steroid receptor coactivator 3 (SRC-3), a …