Targeted protein degradation (TPD) has been established as a viable alternative to
attenuate the function of a specific protein of interest in both biological and clinical contexts …

Autophagy mediates the degradation and recycling of cellular material in the lysosomal
system. Dysfunctional autophagy is associated with a plethora of diseases including …

Cells keep their proteome functional by the action of the proteostasis network, composed of
the chaperones, the ubiquitin-proteasome system and autophagy. The decline of this …

NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in
innate immune signaling, cell death regulation and host-pathogen interactions. Here we …

Abstract Tank-binding kinase 1 (TBK1) is a Ser/Thr kinase that is involved in many
intracellular processes, such as innate immunity, cell cycle, and apoptosis. TBK1 is also …

Autophagy is a major degradative pathway that plays a key role in sustaining cell
homeostasis, integrity, and physiological functions. Macroautophagy, which ensures the …

In eukaryotes, targeting intracellular components for lysosomal degradation by autophagy
represents a catabolic process that evolutionarily regulates cellular homeostasis. The …

TAX1BP1, a multifunctional autophagy adaptor, plays critical roles in different autophagy
processes. As an autophagy receptor, TAX1BP1 can interact with RB1CC1, NAP1, and …

Research into how the young and old differ, and which biomarkers reflect the diverse
biological processes underlying ageing, is a current and fast-growing field. Biological clocks …

Oncogene-induced senescence (OIS) is a persistent anti-proliferative response that acts as
a barrier against malignant transformation. During OIS, cells undergo dynamic remodeling …