PPARγ and the global map of adipogenesis and beyond
MI Lefterova, AK Haakonsson, MA Lazar… - Trends in Endocrinology …, 2014 - cell.com
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
PPARs: fatty acid sensors controlling metabolism
L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
[HTML][HTML] PPARγ in adipocyte differentiation and metabolism–novel insights from genome-wide studies
Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which
PPARγ and members of the C/EBP family are key players. Here we review the roles of …
PPARγ and members of the C/EBP family are key players. Here we review the roles of …
Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading
Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …
Coactivators in PPAR‐regulated gene expression
N Viswakarma, Y Jia, L Bai, A Vluggens… - PPAR …, 2010 - Wiley Online Library
Peroxisome proliferator‐activated receptor (PPAR) α, β (also known as δ), and γ function as
sensors for fatty acids and fatty acid derivatives and control important metabolic pathways …
sensors for fatty acids and fatty acid derivatives and control important metabolic pathways …
PPARs and lipid ligands in inflammation and metabolism
Peroxisome proliferator-activated receptors (PPARs) belong to a family of ligand-activated
nuclear receptors that includes the estrogen, thyroid hormone, and glucocorticoid receptors …
nuclear receptors that includes the estrogen, thyroid hormone, and glucocorticoid receptors …
PPAR-γ partial agonists in disease-fate decision with special reference to cancer
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has emerged as one of the most
extensively studied transcription factors since its discovery in 1990, highlighting its …
extensively studied transcription factors since its discovery in 1990, highlighting its …
General molecular biology and architecture of nuclear receptors
Nuclear receptors (NRs) regulate and coordinate multiple processes by integrating internal
and external signals, thereby maintaining homeostasis in front of nutritional, behavioral and …
and external signals, thereby maintaining homeostasis in front of nutritional, behavioral and …
Cell-specific determinants of peroxisome proliferator-activated receptor γ function in adipocytes and macrophages
MI Lefterova, DJ Steger, D Zhuo… - … and cellular biology, 2010 - Taylor & Francis
The nuclear receptor peroxisome proliferator activator receptor γ (PPARγ) is the target of
antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side effects …
antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side effects …
Isoform-specific functions of PPARγ in gene regulation and metabolism
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital
regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by …
regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by …