Recently, there has been an increasing use of the cyclopropyl ring in drug development to
transition drug candidates from the preclinical to clinical stage. Important features of the …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and painful adverse
reaction of cancer treatment in patients that is little understood or treated. Cytotoxic drugs …

Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …

The necessity of safe and effective treatments for chronic pain has intensified the search for
new analgesic drugs. In the last few years, members of a closely-related family of ion …

Bradykinin, an inflammatory mediator, sensitizes nociceptor peripheral terminals reducing
pain threshold. We now show that the B2 kinin receptor is expressed in rat dorsal horn …

Bradykinin potentiates synaptic glutamate release and action in the spinal cord via
presynaptic and postsynaptic B2 receptors, contributing thereby to activity-dependent central …

Sensory input from the periphery to the CNS is critically dependent on the strength of
synaptic transmission at the first sensory synapse formed between primary afferent dorsal …