As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …

It is well established that the vast majority of human RNA transcripts do not encode for
proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A …

Background miRNAs regulate the expression of several genes with one miRNA able to
target multiple genes and with one gene able to be simultaneously targeted by more than …

Inhibition of tumor growth and normalization of immune responses in the tumor
microenvironment (TME) are critical issues for improving cancer therapy. However, in the …

Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …

MicroRNAs play a key role in the regulation of gene expression. A majority of microRNA–
mRNA interactions remain unidentified. Despite extensive research, our ability to predict …

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Neurodegenerative diseases originate from neuronal loss in the central nervous system
(CNS). These debilitating diseases progress with age and have become common due to an …

MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …