The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …

Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …

The dysregulated expression of immune checkpoint molecules enables cancer cells to
evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 …

Intercellular adhesion molecules play an important role in the generation of T lymphocyte–
mediated immune responses. Here, we describe a novel accessory molecule, DNAX …

Human mesenchymal stem cells (MSCs) have immuno-modulatory properties. They inhibit T-
cell proliferation to mitogens and alloantigens in vitro and prolong skin graft survival in vivo …

Psoriasis vulgaris is the most prevalent T-cell-mediated inflammatory disease in humans.
The pathogenesis of psoriasis is linked to activation of several types of leukocytes that …

While the leukocyte integrin lymphocyte function-associated antigen (LFA)-I has been
demonstrated to bind intercellular adhesion molecule (ICAM)-I, results with the related Mac …

Both the integrins LFA-1 and Mac-l bind to ICAM-1, an immunoglobulin superfamily member.
Previously, we localized the binding sites of LFA-1 and the major group of human …

Neutrophil research relies largely on studies with highly purified cells. Yet the isolation
procedures induce changes in surface expression of several proteins. We used a large …

Recently the human T cell erythrocyte receptor CD2 has been shown to bind human
erythrocytes through LFA-3, a heavily gly-cosylated surface protein of broad tissue …