Cancer biology involves complex, dynamic interactions between cancer cells and their
tissue microenvironments. Single-cell effects are critical drivers of clinical progression …

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs
composed of multiple cell types and extracellular matrix. Some aspects of tumor …

Despite the novel diagnostic methods and therapies implemented in oncology, the number
of patients that succumb by the cancer remains high globally. Currently studies point out that …

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)—a key
lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids—in …

High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …

Histopathologic knowledge that extensive heterogeneity exists between and within tumors
has been confirmed and deepened recently by molecular studies. However, the impact of …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …

We propose that carcinogenesis requires tumour populations to surmount six distinct
microenvironmental proliferation barriers that arise in the adaptive landscapes of normal …

There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …