Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and
deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual …

Global analysis of the susceptibility of influenza viruses to neuraminidase (NA) inhibitors
(NAIs) and the polymerase acidic (PA) inhibitor (PAI) baloxavir was conducted by five World …

Background Single-dose baloxavir rapidly reduces influenza virus titers and symptoms in
patients with uncomplicated influenza, but viruses with reduced in vitro susceptibility due to …

In addition to immunization programs, antiviral agents can play a major role for the control of
seasonal influenza epidemics and may also provide prophylactic and therapeutic benefits …

Background We assessed the safety and effectiveness of baloxavir marboxil administration
in Japanese children with influenza. Methods This open-label study administered 1 weight …

Highlights•Changes in the circulation of antiviral-resistant influenza viruses have
occurred.•All human influenza viruses are currently resistant to the adamantanes.•Little …

Influenza A virus's (IAV's) frequent genetic changes challenge vaccine strategies and
engender resistance to current drugs. We sought to identify conserved and essential RNA …

Abstract Four World Health Organization (WHO) Collaborating Centres for Reference and
Research on Influenza and one WHO Collaborating Centre for the Surveillance …

Influenza poses a significant burden on society and health care systems. Although antivirals
are an integral tool in effective influenza management, the potential for the emergence of …

Antiviral drugs are an important measure of control for influenza in the population,
particularly for those that are severely ill or hospitalised. The neuraminidase inhibitor (NAI) …