Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Inflammation is an immune response that works as a contained fire that is pre-emptively
sparked as a defensive process during infections or upon any kind of tissue insult, and that …

Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …

The end of twentieth century has introduced some changes into T helper (Th) cells division.
The identification of the new subpopulation of T helper cells producing IL-17 modified model …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Chronic inflammation is the basis of various chronic illnesses including cancer and vascular
diseases. However, much has yet to be learned how inflammation becomes chronic …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E 2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …