Immune-related adverse events associated with immune checkpoint blockade

MA Postow, R Sidlow… - New England Journal of …, 2018 - Mass Medical Soc
Side Effects of Immune Checkpoint Blockade The wide range of immune-related adverse
effects associated with immune checkpoint blockade can complicate this effective therapy …

Myasthenia gravis: subgroup classification and therapeutic strategies

NE Gilhus, JJ Verschuuren - The Lancet Neurology, 2015 - thelancet.com
Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and
fatigue, is B-cell mediated, and is associated with antibodies directed against the …

Single-cell eQTL map** identifies cell type–specific genetic control of autoimmune disease

S Yazar, J Alquicira-Hernandez, K Wing, A Senabouth… - Science, 2022 - science.org
The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …

Myasthenia gravis: epidemiology, pathophysiology and clinical manifestations

L Dresser, R Wlodarski, K Rezania… - Journal of clinical medicine, 2021 - mdpi.com
Myasthenia gravis (MG) is an autoimmune neurological disorder characterized by defective
transmission at the neuromuscular junction. The incidence of the disease is 4.1 to 30 cases …

Regulatory T cells in the treatment of disease

A Sharabi, MG Tsokos, Y Ding, TR Malek… - Nature reviews Drug …, 2018 - nature.com
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …

Regulatory T cells in multiple sclerosis and myasthenia gravis

KM Danikowski, S Jayaraman… - Journal of …, 2017 - Springer
Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system
primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically …

[HTML][HTML] The epidemiology of myasthenia gravis

AM Bubuioc, A Kudebayeva… - Journal of medicine …, 2021 - ncbi.nlm.nih.gov
Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to
muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly …

Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants

Y **, G Andersen, D Yorgov, TM Ferrara, S Ben… - Nature …, 2016 - nature.com
Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of
melanocytes, with epidemiological association with other autoimmune diseases. In previous …

Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study

R Chia, S Saez-Atienzar, N Murphy… - Proceedings of the …, 2022 - National Acad Sciences
Myasthenia gravis is a chronic autoimmune disease characterized by autoantibody-
mediated interference of signal transmission across the neuromuscular junction. We …

Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society

N Melzer, T Ruck, P Fuhr, R Gold, R Hohlfeld… - Journal of …, 2016 - Springer
Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular
synaptic transmission. The clinical hallmark of MG consists of fluctuating fatigability and …