Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Prions, the infectious agents of transmissible spongiform encephalopathies (TSEs), have
defied full characterization for decades. The dogma has been that prions lack nucleic acids …

The integrity of peripheral nerves relies on communication between axons and Schwann
cells. The axonal signals that ensure myelin maintenance are distinct from those that direct …

The key pathogenic event in prion disease involves misfolding and aggregation of the
cellular prion protein (PrP). Beyond this fundamental observation, the mechanism by which …

The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

The recently developed engineered nucleases, such as zinc-finger nucleases, transcription
activator-like effector nucleases, and clustered regularly interspaced short palindromic …

Prnp−/− mice lack the prion protein PrPC and are resistant to prion infections, but variable
phenotypes have been reported in Prnp−/− mice and the physiological function of PrPC …

Susceptibility of cervids to Chronic Wasting Disease (CWD), a prion disease, can be
modulated by variations in the prion protein gene (PRNP), encoding the cellular prion …

Selective breeding and genetic modification have been the cornerstone of animal
agriculture. However, the current strategy of breeding animals over multiple generations to …

Chronic stress has become a predominant factor associated with a variety of psychiatric
disorders, such as depression and anxiety, in both human and animal models. Although …