Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm

TA Quinn, P Kohl - Physiological reviews, 2021‏ - journals.physiology.org
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

[HTML][HTML] Cardiomyocyte calcium handling in health and disease: Insights from in vitro and in silico studies

H Sutanto, A Lyon, J Lumens, U Schotten… - Progress in biophysics …, 2020‏ - Elsevier
Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023‏ - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

Features from the photoplethysmogram and the electrocardiogram for estimating changes in blood pressure

E Finnegan, S Davidson, M Harford, P Watkinson… - Scientific Reports, 2023‏ - nature.com
There is a growing emphasis being placed on the potential for cuffless blood pressure (BP)
estimation through modelling of morphological features from the photoplethysmogram (PPG) …

In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

F Margara, ZJ Wang… - … in biophysics and …, 2021‏ - pmc.ncbi.nlm.nih.gov
Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …

A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics

F Mazhar, C Bartolucci, F Regazzoni… - The Journal of …, 2024‏ - Wiley Online Library
Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

[HTML][HTML] Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

M Salvador, M Fedele, PC Africa, E Sung… - Computers in Biology …, 2021‏ - Elsevier
We developed a novel patient-specific computational model for the numerical simulation of
ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model …

[HTML][HTML] The role of mechano-electric feedbacks and hemodynamic coupling in scar-related ventricular tachycardia

M Salvador, F Regazzoni, S Pagani… - Computers in Biology …, 2022‏ - Elsevier
Abstract Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are
transduced into electrical signals, have received sparse investigation by considering …

Differential effects of mechano‐electric feedback mechanisms on whole‐heart activation, repolarization, and tension

T Gerach, A Loewe - The Journal of Physiology, 2024‏ - Wiley Online Library
The human heart is subject to highly variable amounts of strain during day‐to‐day activities
and needs to adapt to a wide range of physiological demands. This adaptation is driven by …

A fully-coupled electro-mechanical whole-heart computational model: Influence of cardiac contraction on the ecg

R Moss, EM Wülfers, S Schuler, A Loewe… - Frontiers in …, 2021‏ - frontiersin.org
The ECG is one of the most commonly used non-invasive tools to gain insights into the
electrical functioning of the heart. It has been crucial as a foundation in the creation and …