Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …

Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …

A defining pathological feature of most neurodegenerative diseases is the assembly of
proteins into amyloid that form disease-specific structures. In Alzheimer's disease, this is …

Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Alzheimer's disease (AD) is a serious neurodegenerative disease characterized by memory
impairment, mental retardation, impaired motor balance, loss of self-care and even death …

Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …

Abstract Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial
activation in the central nervous system (CNS). We previously demonstrated the crucial …

Autophagy, the major lysosomal pathway for degrading damaged or obsolete constituents,
protects neurons by eliminating toxic organelles and peptides, restoring nutrient and energy …

Abstract Early-onset (age< 65) Alzheimer's disease is associated with greater non-amnestic
cognitive symptoms and neuropathological burden than late-onset disease. It is not fully …