The cardiac muscle and the coronary vasculature are in close proximity to each other, and a
two-way interaction, called cross-talk, exists. Here we focus on the mechanical aspects of …

Myocardial ischemia is commonly associated with coronary artery disease as well as many
congenital and acquired heart diseases without obstructed coronary arteries. With brief …

Myocardial ischemia is transmurally heterogeneous where the subendocardium is at higher
risk. Stenosis induces reduced perfusion pressure, blood flow redistribution away from the …

Objective Aortic stiffness can lead to low diastolic blood pressure, thereby possibly limiting
coronary perfusion. Therefore, the simultaneous occurrence of both aortic stiffness and …

Background Experimental studies have demonstrated that during stress-induced myocardial
ischemia, coronary obstruction and diastolic perfusion time are factors that limit …

Coronary flow reserve is used to aid understanding why myocardial oxygen consumption
may fail to meet demand. Its general aspects are well known, but the problems of using it are …

In 10 anesthetized dogs, we measured high-fidelity left circumflex coronary (PLCx), aortic
(PAo), and left ventricular (PLV) pressures and left circumflex velocity (U LCx; Doppler) and …

Myocardial infarction (MI) rapidly impairs cardiac contractile function and instigates
maladaptive remodeling leading to heart failure. Patient-specific models are a maturing …

To clarify the source of electrocardiographic ST depression associated with ischemia, a
sheep model of subendocardial ischemia was developed in which simultaneous epicardial …

Multiscale modeling is a promising tool for the study of coronary hemodynamics. A key
strength of this approach is that it accounts for microvascular properties and extravascular …