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High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities
The human gut microbiome is a key contributor to health, and its perturbations are linked to
many diseases. Small-molecule xenobiotics such as drugs, chemical pollutants and food …
many diseases. Small-molecule xenobiotics such as drugs, chemical pollutants and food …
Microbial transformation of dietary xenobiotics shapes gut microbiome composition
Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome
interactions may contribute to variation in their health consequences. To mechanistically …
interactions may contribute to variation in their health consequences. To mechanistically …
Cutting-edge tools for unveiling the dynamics of plasmid–host interactions
QE Yang, JT Gao, SG Zhou, TR Walsh - Trends in Microbiology, 2025 - cell.com
The plasmid-mediated transfer of antibiotic resistance genes (ARGs) in complex
microbiomes presents a significant global health challenge. This review examines recent …
microbiomes presents a significant global health challenge. This review examines recent …
Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts)
AB Narrowe, JMS Lemons, KK Mahalak… - Frontiers in Cellular …, 2024 - frontiersin.org
The genus Senna contains globally distributed plant species of which the leaves, roots, and
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …
Nutrient competition predicts gut microbiome restructuring under drug perturbations
Human gut commensal bacteria are routinely exposed to various stresses, including
therapeutic drugs, and collateral effects are difficult to predict. To systematically interrogate …
therapeutic drugs, and collateral effects are difficult to predict. To systematically interrogate …