High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities

P Müller, J de la Cuesta-Zuluaga, M Kuhn… - Nature …, 2024 - nature.com
The human gut microbiome is a key contributor to health, and its perturbations are linked to
many diseases. Small-molecule xenobiotics such as drugs, chemical pollutants and food …

Microbial transformation of dietary xenobiotics shapes gut microbiome composition

EJ Culp, NT Nelson, AA Verdegaal, AL Goodman - Cell, 2024 - cell.com
Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome
interactions may contribute to variation in their health consequences. To mechanistically …

Cutting-edge tools for unveiling the dynamics of plasmid–host interactions

QE Yang, JT Gao, SG Zhou, TR Walsh - Trends in Microbiology, 2025 - cell.com
The plasmid-mediated transfer of antibiotic resistance genes (ARGs) in complex
microbiomes presents a significant global health challenge. This review examines recent …

Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts)

AB Narrowe, JMS Lemons, KK Mahalak… - Frontiers in Cellular …, 2024 - frontiersin.org
The genus Senna contains globally distributed plant species of which the leaves, roots, and
seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds …

Nutrient competition predicts gut microbiome restructuring under drug perturbations

H Shi, DP Newton, TH Nguyen, S Estrela, J Sanchez… - bioRxiv, 2024 - biorxiv.org
Human gut commensal bacteria are routinely exposed to various stresses, including
therapeutic drugs, and collateral effects are difficult to predict. To systematically interrogate …