Presbycusis, or age‐related hearing loss (ARHL), occurs in most mammals with variations in
the age of onset, rate of decline, and magnitude of degeneration in the central nervous …

The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Age-related hearing loss arises from irreversible damage in the inner ear, where sound is
transduced into electrical signals. Prior human studies suggested that sensory-cell loss is …

Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …

Aging listeners experience greater difficulty understanding speech in adverse listening
conditions and exhibit degraded temporal resolution, even when audiometric thresholds are …

Acoustic overexposure can cause a permanent loss of auditory nerve fibers without
destroying cochlear sensory cells, despite complete recovery of cochlear thresholds, as …

Recent animal work has suggested that cochlear synapses are more vulnerable than hair
cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in …

Overexposure to intense sound can cause temporary or permanent hearing loss.
Postexposure recovery of threshold sensitivity has been assumed to indicate reversal of …