Protein phosphatase 2A: a target for anticancer therapy
Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
Sphingolipids: regulators of crosstalk between apoptosis and autophagy
MM Young, M Kester, HG Wang - Journal of lipid research, 2013 - ASBMB
Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
homeostasis during stress. Although the two pathways utilize fundamentally distinct …
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …
The key role of sphingolipid metabolism in cancer: New therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance
RZ Li, XR Wang, J Wang, C **e, XX Wang… - Frontiers in …, 2022 - frontiersin.org
Biologically active sphingolipids are closely related to the growth, differentiation, aging, and
apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites …
apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites …
FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells
Y Zhong, F Tian, H Ma, H Wang, W Yang, Z Liu, A Liao - Life sciences, 2020 - Elsevier
Aims Multiple myeloma (MM) is the second hematological plasma cell malignany and
sensitive to fingolimod (FTY720), a novel immunosuppressant. Previous study shows …
sensitive to fingolimod (FTY720), a novel immunosuppressant. Previous study shows …
[HTML][HTML] Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …
catalyzes the selective removal of phosphate groups from protein serine and threonine …
Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling …
L Zhang, H Wang, J Xu, J Zhu, K Ding - Toxicology letters, 2014 - Elsevier
Cathepsin S is a lysosomal cysteine protease that is overexpressed in various cancer
models and plays important role in tumorigenesis, however the mechanisms are unclear. In …
models and plays important role in tumorigenesis, however the mechanisms are unclear. In …
Molecular pharmacology and novel potential therapeutic applications of fingolimod
Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …
HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma
B Pan, D Chen, J Huang, R Wang, B Feng, H Song… - Molecular cancer, 2014 - Springer
Background Docetaxel resistance remains a major obstacle in the treatment of non-small
cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote …
cell lung cancer (NSCLC). High-mobility group box 1 (HMGB1) has been shown to promote …
[HTML][HTML] Ceramide species are elevated in human breast cancer and are associated with less aggressiveness
Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death.
Although important roles of sphingolipids in breast cancer progression have been reported …
Although important roles of sphingolipids in breast cancer progression have been reported …