Selenoproteins: molecular pathways and physiological roles
VM Labunskyy, DL Hatfield… - Physiological …, 2014 - journals.physiology.org
Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …
relevance to several pathophysiological conditions. The biological effects of selenium are …
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …
Emerging roles of energy metabolism in ferroptosis regulation of tumor cells
X Yao, W Li, D Fang, C **ao, X Wu, M Li… - Advanced …, 2021 - Wiley Online Library
Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐
dependent accumulation of lethal lipid peroxides and involved in many critical diseases …
dependent accumulation of lethal lipid peroxides and involved in many critical diseases …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Oxidant signals and oxidative stress
T Finkel - Current opinion in cell biology, 2003 - Elsevier
Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …
fashion, growing evidence suggests that in many instances the production of reactive …
Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins
Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …
Targeting the thioredoxin system for cancer therapy
Thioredoxin (Trx) and thioredoxin reductase (TrxR) are essential components of the Trx
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
system which plays pivotal roles in regulating multiple cellular redox signaling pathways. In …
Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
aerobic metabolism, as a result of accidental electron leakage as well as regulated …
Selenoproteins
J Lu, A Holmgren - Journal of Biological Chemistry, 2009 - ASBMB
Selenium is an essential micronutrient for man and animals. The role of selenium has been
attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine …
attributed largely to its presence in selenoproteins as the 21st amino acid, selenocysteine …
Thioredoxin and related molecules–from biology to health and disease
Thioredoxin and glutaredoxin systems in mammalian cells utilize thiol and selenol groups to
maintain a reducing intracellular redox state acting as antioxidants and reducing agents in …
maintain a reducing intracellular redox state acting as antioxidants and reducing agents in …