Age-related macular degeneration

P Mitchell, G Liew, B Gopinath, TY Wong - The Lancet, 2018 - thelancet.com
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …

Defining response to anti-VEGF therapies in neovascular AMD

WM Amoaku, U Chakravarthy, R Gale, M Gavin… - Eye, 2015 - nature.com
The introduction of anti-vascular endothelial growth factor (anti-VEGF) has made significant
impact on the reduction of the visual loss due to neovascular age-related macular …

Predicting conversion to wet age-related macular degeneration using deep learning

J Yim, R Chopra, T Spitz, J Winkens, A Obika, C Kelly… - Nature Medicine, 2020 - nature.com
Progression to exudative 'wet'age-related macular degeneration (exAMD) is a major cause
of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an …

Prediction of individual disease conversion in early AMD using artificial intelligence

U Schmidt-Erfurth, SM Waldstein… - … & visual science, 2018 - iovs.arvojournals.org
Purpose: While millions of individuals show early age-related macular degeneration (AMD)
signs, yet have excellent vision, the risk of progression to advanced AMD with legal …

[HTML][HTML] Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors

H Mehta, A Tufail, V Daien, AY Lee, V Nguyen… - Progress in retinal and …, 2018 - Elsevier
Clinical trials identified intravitreal vascular endothelial growth factor inhibitors (anti-VEGF
agents) have the potential to stabilise or even improve visual acuity outcomes in …

[HTML][HTML] Visual acuity outcomes and anti–vascular endothelial growth factor therapy intensity in neovascular age-related macular degeneration patients: a real-world …

TA Ciulla, RM Hussain, JS Pollack, DF Williams - Ophthalmology Retina, 2020 - Elsevier
Purpose This study assessed anti–vascular endothelial growth factor (VEGF) therapy
intensity and its relationship with visual acuity (VA) change in real-world neovascular age …

Metaanalysis of real-world outcomes of intravitreal ranibizumab for the treatment of neovascular age-related macular degeneration

LN Kim, H Mehta, D Barthelmes, V Nguyen, MC Gillies - Retina, 2016 - journals.lww.com
Purpose: To report the efficacy and safety of intravitreal ranibizumab for neovascular age-
related macular degeneration (nAMD) in real-world practice. Methods: Metaanalysis of∼ …

Innovative therapies for neovascular age-related macular degeneration

H Al-Khersan, RM Hussain, TA Ciulla… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Investigational anti-VEGF treatments for neovascular age-related macular
degeneration (nAMD) aim to improve visual outcomes and reduce treatment burden; these …

Vascular endothelial growth factor antagonists: promising players in the treatment of neovascular age-related macular degeneration

RM Hussain, BA Shaukat, LM Ciulla… - Drug design …, 2021 - Taylor & Francis
Neovascular age-related macular degeneration (nAMD) treatment has been revolutionized
by the introduction of vascular endothelial growth factor antagonists (anti-VEGF), but the …

Dual antagonism of PDGF and VEGF in neovascular age-related macular degeneration: a phase IIb, multicenter, randomized controlled trial

GJ Jaffe, TA Ciulla, AP Ciardella, F Devin, PU Dugel… - Ophthalmology, 2017 - Elsevier
Purpose To assess the safety and efficacy of E10030 (Fovista; Ophthotech, New York, NY), a
platelet-derived growth factor (PDGF) antagonist, administered in combination with the anti …