The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Selective extraction of bioactive compounds from plants using recent extraction techniques: A review

T Lefebvre, E Destandau, E Lesellier - Journal of Chromatography A, 2021 - Elsevier
Plant extraction has existed for a long time and is still of interest. Due to technological
improvements, it is now possible to obtain extracts with higher yields. While global yield is a …

Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

[HTML][HTML] Cannabidiol in anxiety and sleep: a large case series

S Shannon, N Lewis, H Lee, S Hughes - The Permanente Journal, 2019 - ncbi.nlm.nih.gov
Design A large retrospective case series at a psychiatric clinic involving clinical application
of CBD for anxiety and sleep complaints as an adjunct to usual treatment. The retrospective …

Cannabidiol adverse effects and toxicity

MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …

Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort

JD Symonds, SM Zuberi, K Stewart, A McLellan… - Brain, 2019 - academic.oup.com
Epilepsy is common in early childhood. In this age group it is associated with high rates of
therapy-resistance, and with cognitive, motor, and behavioural comorbidity. A large number …

Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial

O Devinsky, E Marsh, D Friedman, E Thiele… - The Lancet …, 2016 - thelancet.com
Background Almost a third of patients with epilepsy have a treatment-resistant form, which is
associated with severe morbidity and increased mortality. Cannabis-based treatments for …

[HTML][HTML] Cannabidiol as a potential treatment for anxiety disorders

EM Blessing, MM Steenkamp, J Manzanares… - …, 2015 - Elsevier
Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum
drug that in recent years has drawn increasing interest as a treatment for a range of …