Progress in intra-articular therapy

CH Evans, VB Kraus, LA Setton - Nature Reviews Rheumatology, 2014‏ - nature.com
Diarthrodial joints are well suited to intra-articular injection, and the local delivery of
therapeutics in this fashion brings several potential advantages to the treatment of a wide …

Mesenchymal stem cells in joint disease and repair

F Barry, M Murphy - Nature Reviews Rheumatology, 2013‏ - nature.com
Osteoarthritis (OA), a prevalent chronic condition with a striking impact on quality of life,
represents an enormous societal burden that increases greatly as populations age. Yet no …

Stem cells in veterinary medicine—current state and treatment options

M Voga, N Adamic, M Vengust… - Frontiers in veterinary …, 2020‏ - frontiersin.org
Regenerative medicine is a branch of medicine that develops methods to grow, repair, or
replace damaged or diseased cells, organs or tissues. It has gained significant momentum …

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

CJ Rogers, RJ Harman, BA Bunnell… - Journal of translational …, 2020‏ - Springer
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei
province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per …

Roles of mesenchymal stem cells in tissue regeneration and immunomodulation

AP Ayala-Cuellar, JH Kang, EB Jeung… - Biomolecules & …, 2018‏ - pmc.ncbi.nlm.nih.gov
Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to
transdifferentiate into various lineages that develop from mesoderm. Their popular appeal …

Concise review: stem cell trials using companion animal disease models

AM Hoffman, SW Dow - Stem cells, 2016‏ - academic.oup.com
Studies to evaluate the therapeutic potential of stem cells in humans would benefit from
more realistic animal models. In veterinary medicine, companion animals naturally develop …

Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model

G Desando, C Cavallo, F Sartoni, L Martini… - Arthritis research & …, 2013‏ - Springer
Introduction Cell therapy is a rapidly growing area of research for the treatment of
osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose …

Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants

CS Lin, G Lin, TF Lue - Stem cells and development, 2012‏ - liebertpub.com
Mesenchymal stem cells (MSCs) are well known for their immunomodulatory capabilities. In
particular, their immunosuppressive property is believed to permit their allogeneic or even …

Large animal models for stem cell therapy

J Harding, RM Roberts, O Mirochnitchenko - Stem cell research & therapy, 2013‏ - Springer
The field of regenerative medicine is approaching translation to clinical practice, and
significant safety concerns and knowledge gaps have become clear as clinical practitioners …

Mesenchymal stem cell therapy for osteoarthritis: current perspectives

CC Wyles, MT Houdek, A Behfar… - Stem cells and cloning …, 2015‏ - Taylor & Francis
Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life.
The societal burden imposed by OA is increasing in parallel with the aging population; …