Radiopharmaceutical therapy in cancer: clinical advances and challenges

G Sgouros, L Bodei, MR McDevitt… - Nature reviews Drug …, 2020‏ - nature.com
Radiopharmaceutical therapy (RPT) is emerging as a safe and effective targeted approach
to treating many types of cancer. In RPT, radiation is systemically or locally delivered using …

Auger electrons for cancer therapy–a review

A Ku, VJ Facca, Z Cai, RM Reilly - EJNMMI radiopharmacy and chemistry, 2019‏ - Springer
Abstract Background Auger electrons (AEs) are very low energy electrons that are emitted
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …

EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor-and PSMA-targeting ligands

K Sjögreen Gleisner, N Chouin, PM Gabina… - European journal of …, 2022‏ - Springer
The purpose of the EANM Dosimetry Committee is to provide recommendations and
guidance to scientists and clinicians on patient-specific dosimetry. Radiopharmaceuticals …

Prostate-specific membrane antigen radioligand therapy using 177Lu-PSMA I&T and 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer …

C Schuchardt, J Zhang, HR Kulkarni… - Journal of Nuclear …, 2022‏ - jnm.snmjournals.org
The objective of this study was to determine the safety, kinetics, and dosimetry of the 177Lu-
labeled prostate-specific membrane antigen (PSMA) small molecules 177Lu-PSMA I&T and …

Clinical, dosimetric, and reporting considerations for Y-90 glass microspheres in hepatocellular carcinoma: updated 2022 recommendations from an international …

R Salem, SA Padia, M Lam, C Chiesa, P Haste… - European journal of …, 2023‏ - Springer
Purpose In light of recently published clinical reports and trials, the TheraSphere Global
Dosimetry Steering Committee (DSC) reconvened to review new data and to update …

Relationship of tumor radiation–absorbed dose to survival and response in hepatocellular carcinoma treated with transarterial radioembolization with 90Y in the …

AL Hermann, A Dieudonné, M Ronot, M Sanchez… - Radiology, 2020‏ - pubs.rsna.org
Background Little is known about factors that influence the efficacy of transarterial
radioembolization (TARE). Purpose To determine the relationship between tumor radiation …

Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer

Z Szabo, E Mena, SP Rowe, D Plyku, R Nidal… - Molecular imaging and …, 2015‏ - Springer
Purpose Prostate-specific membrane antigen (PSMA) is a recognized target for imaging
prostate cancer. Here we present initial safety, biodistribution, and radiation dosimetry …

Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients

C Meyer, M Dahlbom, T Lindner… - Journal of Nuclear …, 2020‏ - jnm.snmjournals.org
Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …

Highly sensitive detection of ionizing radiations by a photoluminescent uranyl organic framework

J **e, Y Wang, W Liu, X Yin, L Chen, Y Zou… - Angewandte …, 2017‏ - Wiley Online Library
Precise detection of low‐dose X‐and γ‐radiations remains a challenge and is particularly
important for studying biological effects under low‐dose ionizing radiation, safety control in …

ICRU REPORT 96, dosimetry-guided radiopharmaceutical therapy

G Sgouros, WE Bolch, A Chiti… - Journal of the …, 2021‏ - journals.sagepub.com
The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …