Death by TNF: a road to inflammation
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …
that neutralize TNF are among the most successful drugs for the treatment of chronic …
The inflammatory pathogenesis of colorectal cancer
M Schmitt, FR Greten - Nature Reviews Immunology, 2021 - nature.com
The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …
made about the survival of patients or their response to therapy. Instead, studying the …
NF‐κB signaling in inflammation and cancer
T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …
in 1986, extraordinary efforts have been made to understand the function and regulating …
Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome
Inflammatory bowel disease (IBD) is a chronic complex inflammatory gut pathological
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …
condition, examples of which include Crohn's disease (CD) and ulcerative colitis (UC) …
Interaction between the microbiota, epithelia, and immune cells in the intestine
H Kayama, R Okumura, K Takeda - Annual review of …, 2020 - annualreviews.org
The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …
microbiota, that benefit host health by digesting dietary components and eliminating …
Cell death in the gut epithelium and implications for chronic inflammation
The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …
Cytokine networks in the pathophysiology of inflammatory bowel disease
M Friedrich, M Pohin, F Powrie - Immunity, 2019 - cell.com
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …
NF-κB signaling in inflammation
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
Gut microbiota and IBD: causation or correlation?
J Ni, GD Wu, L Albenberg, VT Tomov - Nature reviews Gastroenterology …, 2017 - nature.com
A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
Z Ren, A Li, J Jiang, L Zhou, Z Yu, H Lu, H **e, X Chen… - Gut, 2019 - gut.bmj.com
Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC)
and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We …
and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We …