Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
New insights into the pathogenesis of Alzheimer's disease
L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …
Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
M Goedert - Science, 2015 - science.org
BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …
Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
W Qiang, WM Yau, JX Lu, J Collinge, R Tycko - Nature, 2017 - nature.com
Aggregation of amyloid-β peptides into fibrils or other self-assembled states is central to the
pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40-and 42-residue amyloid-β …
pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40-and 42-residue amyloid-β …
Aβ (1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
Increasing evidence has suggested that formation and propagation of misfolded aggregates
of 42-residue human amyloid β (Aβ (1–42)), rather than of the more abundant Aβ (1–40) …
of 42-residue human amyloid β (Aβ (1–42)), rather than of the more abundant Aβ (1–40) …
Interactions of pathological proteins in neurodegenerative diseases
Neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal lobar
degeneration (FTD), Lewy body disease (LBD), Parkinson's disease (PD), and amyotrophic …
degeneration (FTD), Lewy body disease (LBD), Parkinson's disease (PD), and amyotrophic …
Targeting protein aggregation for the treatment of degenerative diseases
YS Eisele, C Monteiro, C Fearns… - Nature reviews Drug …, 2015 - nature.com
The aggregation of specific proteins is hypothesized to underlie several degenerative
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
diseases, which are collectively known as amyloid disorders. However, the mechanistic …
1001 lights: luciferins, luciferases, their mechanisms of action and applications in chemical analysis, biology and medicine
ZM Kaskova, AS Tsarkova, IV Yampolsky - Chemical Society Reviews, 2016 - pubs.rsc.org
Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …
[HTML][HTML] Amyloid polymorphism: structural basis and neurobiological relevance
R Tycko - Neuron, 2015 - cell.com
Our understanding of the molecular structures of amyloid fibrils that are associated with
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
neurodegenerative diseases, of mechanisms by which disease-associated peptides and …
Neurodegenerative diseases: expanding the prion concept
LC Walker, M Jucker - Annual review of neuroscience, 2015 - annualreviews.org
The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …