Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Summary Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but
the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Adenosine receptors are major targets of caffeine, the most commonly consumed drug in the
world. There is growing evidence that they could also be promising therapeutic targets in a …

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

Purinergic receptors, represented by several families, are arguably the most abundant
receptors in living organisms and appeared early in evolution. After slow acceptance …

Adenosine triphosphate (ATP) is actively released in the extracellular environment in
response to tissue damage and cellular stress. Through the activation of P2X and P2Y …

CD73 is a cell-surface enzyme that suppresses immune responses by producing
extracellular adenosine. In this study, we employed CD73 gene-targeted mice to investigate …

Since its discovery in 1945, methotrexate has become a standard therapy for number of
diseases, including oncological, inflammatory and pulmonary ones. Major physiological …