The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …

Open-label placebos (OLPs) are placebos without deception in the sense that patients know
that they are receiving a placebo. The objective of our study is to systematically review and …

As conversational agents powered by large language models become more human-like,
users are starting to view them as companions rather than mere assistants. Our study …

Objectives To characterize individual participant level response distributions to acute
monotherapy for major depressive disorder in randomized, placebo controlled trials …

Background Contextual effects (ie, placebo response) refer to all health changes resulting
from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the …

The aim of this review is to evaluate the placebo effect in the treatment of anxiety and
depression. Antidepressants are supposed to work by fixing a chemical imbalance …

The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Rationale The biopsychosocial (BPS) model that challenged the historically dominant
biomedical model remains influential today. This model considers biological, psychological …

Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the
use of analgesic treatments in clinical practice. In this article, we report on an Initiative on …

Abstract After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms
indicate numerous affected organ systems. After a year, chronic fatigue, dysautonomia and …