The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal
organization. In order to explore the molecular mechanism underlying this regulation, we …

We describe an approach to manipulate and measure mechanical interactions between
cells and their underlying substrates by using microfabricated arrays of elastomeric …

Recent technological improvements in the elastic substrate method make it possible to
produce spatially resolved measurements of the tractions exerted by single motile cells. In …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Fibroblasts are one of the most abundant cell types in connective tissues. These cells are
responsible for tissue homeostasis under normal physiological conditions. When tissues are …

We measure dynamic traction forces exerted by epithelial cells on a substrate. The force
sensor is a high-density array of elastomeric microfabricated pillars that support the cells …