After the first aminoglycoside antibiotic streptomycin being applied in clinical practice in the
mid-1940s, aminoglycoside antibiotics (AGAs) are widely used to treat clinical bacterial …

Aminoglycosides (AGs) are long-known molecules successfully used against Gram-negative
pathogens. While their use declined with the discovery of new antibiotics, they are now …

The development of effective antibacterial solutions has become paramount in maintaining
global health in this era of increasing bacterial threats and rampant antibiotic resistance …

There is a need to discover and develop non-toxic antibiotics that are effective against
metabolically dormant bacteria, which underlie chronic infections and promote antibiotic …

The detection and monitoring of aminoglycoside antibiotics (AGAs) have become of utmost
importance due to their widespread use in human and animal therapy, as well as the …

Antibiotics have received much attention owing to their ecotoxicity toward nontarget aquatic
creatures. However, the mode of action (MOA) of toxicity against nontarget organisms is …

Background Francisella tularensis, the causative agent of tularemia, is endemic throughout
the Northern Hemisphere and requires as few as 10 organisms to cause disease, making …

Biofilms related to human infection have high levels of pathogenicity due to their resistance
to antimicrobial agents. The discovery of antibiofilm agents is necessary. One approach to …

The overuse of antibiotics combined with the limitation of wastewater facilities has resulted
in drug residue accumulation in the natural environment. Thus, in recent years, the presence …

Antibiotic abuse is becoming increasingly serious and the potential for harm to human
health and the environment has aroused widespread social concern. Aminoglycoside …