Increasing evidence sustains that the establishment and maintenance of many, if not all,
human cancers are due to cancer stem cells (CSCs), tumor cells with stem cell properties …

Veterinarians and veterinary medicine have been integral to the development of stem cell
therapies. The contributions of large animal experimental models to the development and …

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving
rise to the next generation in mammals and many other multicellular organisms. How germ …

The preimplantation development of mammals generally follows the same plan. It starts with
the formation of a totipotent zygote, and through consecutive cleavage divisions and …

The potential use of stem cells (SCs) for tissue engineering, regenerative medicine, disease
modeling, toxicological studies, drug delivery, and as in vitro model for the study of basic …

The derivation and study of human embryonic stem cell lines, despite their potential
therapeutic usefulness, raise considerable ethical, religious, legal and political concerns …

Recently, we proposed that rabbit embryonic stem (ES) cells can be stable mammalian ES
cells and can be a small animal model for human ES cell research. However, the signaling …

Not much is known about the molecular and functional features of pluripotent stem cells
(PSCs) in rabbits. To address this, we derived and characterized 2 types of rabbit PSCs from …

Although embryonic stem (ES) cell lines derived from mice and primates are used
extensively, the development of such lines from other mammals is extremely difficult …

The rabbit has been recognized as a valuable model in various biomedical and biological
research fields because of its intermediate size and phylogenetic proximity to primates …