Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous
system that plays a critical role in the physiological brain functions via its two independent …

Animal and clinical studies have confirmed the therapeutic effect of bone marrow
mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly …

Cell-based therapy exploits modified human cells to treat diseases but its targeted
application in specific tissues, particularly those lying deep in the body where direct injection …

The central nervous system (CNS) can be injured or damaged through a variety of insults
including traumatic injury, stroke, and neurodegenerative or demyelinating diseases …

Stem cell therapy is a promising treatment for neurological disorders such as cerebral
ischemia, Parkinson's disease and Huntington's disease. In recent years, many clinical trials …

Stem cells combined with biodegradable injectable scaffolds releasing growth factors hold
great promises in regenerative medicine, particularly in the treatment of neurological …

Human muscle-derived progenitor cells (hMDPCs) offer great promise for muscle cell-based
regenerative medicine; however, prolonged ex-vivo expansion using animal sera is …

The use of injectable scaffolding materials for in vivo tissue regeneration has raised great
interest in various clinical applications because it allows cell implantation through minimally …

Few effective therapeutic interventions are available to limit brain damage and functional
deficits after ischaemic stroke. Within this context, mesenchymal stem cell (MSC) therapy …

The challenge of tissue engineering of the infarcted heart is how to improve stem cell
engraftment, survival, homing, and differentiation for myocardial repair. We here propose to …