In solid cancers, invasion and metastasis account for more than 90% of mortality. However,
in the current armory of anticancer therapies, a specific category of anti-invasion and …

Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin
filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to …

Actin is a key structural protein that makes up the cytoskeleton of cells, and plays a role in
functions such as division, migration, and vesicle trafficking. It comprises six different cell …

Most cancer-related deaths among patients with solid tumors are caused by metastases.
Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer …

A common feature of cancer cells is the alteration of kinases and biochemical signalling
pathways enabling transformed growth on soft matrices, whereas cytoskeletal protein …

Cytoskeletal proteins, which consist of different sub-families of proteins including
microtubules, actin and intermediate filaments, are essential for survival and cellular …