Cell-surface interactions on arginine-rich cell-penetrating peptides allow for multiplex modes of internalization

S Futaki, I Nakase - Accounts of chemical research, 2017 - ACS Publications
Conspectus One of the recent hot topics in peptide-related chemical biology research is the
potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery

T Jiang, Z Zhang, Y Zhang, H Lv, J Zhou, C Li, L Hou… - Biomaterials, 2012 - Elsevier
Dual-functional liposomes with pH-responsive cell-penetrating peptide (CPP) and active
targeting hyaluronic acid (HA) were fabricated for tumor-targeted drug delivery. A series of …

Transient focal membrane deformation induced by arginine-rich peptides leads to their direct penetration into cells

H Hirose, T Takeuchi, H Osakada, S Pujals… - Molecular Therapy, 2012 - cell.com
Endocytosis has been implicated in the cellular uptake of arginine-rich, cell-penetrating
peptides (CPPs). However, accumulating evidence suggests that certain conditions allow …

Nanoparticles esca** RES and endosome: challenges for siRNA delivery for cancer therapy

S Guo, L Huang - Journal of Nanomaterials, 2011 - Wiley Online Library
Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …

Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system

I Szabó, M Yousef, D Soltész, C Bató, G Mező… - Pharmaceutics, 2022 - mdpi.com
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Fluoroalkylation promotes cytosolic peptide delivery

G Rong, C Wang, L Chen, Y Yan, Y Cheng - Science Advances, 2020 - science.org
Cytosolic delivery of peptides remains a challenging task owing to their susceptibility to
enzymatic degradation and the existence of multiple intracellular barriers. Here, we report a …

A review of lipidation in the development of advanced protein and peptide therapeutics

R Menacho-Melgar, JS Decker, JN Hennigan… - Journal of Controlled …, 2019 - Elsevier
The use of biologics (peptide and protein based drugs) has increased significantly over the
past few decades. However, their development has been limited by their short half-life …

Intracellular delivery of quantum dots mediated by a histidine-and arginine-rich HR9 cell-penetrating peptide through the direct membrane translocation mechanism

BR Liu, Y Huang, JG Winiarz, HJ Chiang, HJ Lee - Biomaterials, 2011 - Elsevier
Functional peptides that transfer biomaterials, such as semiconductor quantum dots (QDs),
into cells in biomaterial research have been developed in recent years. Delivery of QDs …

Cell-penetrating peptides as valuable tools for nose-to-brain delivery of biological drugs

LB De Martini, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Due to their high specificity toward the target and their low toxicity, biological drugs have
been successfully employed in a wide range of therapeutic areas. It is yet to be mentioned …