Cyclosporin is a lipophilic cyclic polypeptide which produces calcium-dependent, specific,
reversible inhibition of transcription of interleukin-2 and several other cytokines, most …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

The nonobese diabetic (NOD) mouse, a model of human type I diabetes, develops insulitis
beginning at 4–6 wk of age. By 30 wk of age, 72% of females and 39% of males develop …

Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a
monoclonal antibody against the L3T4 determinant present on the surface of T-helper …

We have attempted to illustrate the major trends in research in human IDDM and in the
animal models of this disease. We have stressed the utility and importance of the animal …

To investigate the role of RT6+ T cells in the pathogenesis of diabetes in BB/W rats, we
treated animals from the diabetes-resistant (DR) subline with anti-RT6. 1 lymphocytotoxic …

Cyclosporin A (CyA) may induce clinical remission in newly diagnosed insulin-dependent
diabetes mellitus patients. Recently, however, adverse effects of high doses of CyA on …

The BioBreeding rat develops a spontaneous syndrome resembling human type I diabetes
mellitus. Salient features include abrupt onset of insulin dependent, ketosis-prone diabetes …

Summary In the Canadian/European randomized controlled study on cyclosporin A (CsA) in
recent onset Type 1 (insulin-dependent) diabetes, treatment with the immunosuppressive …

In a study of prevention of spontaneous diabetes in BB rats by therapeutic doses of
cyclosporine (10 mg/kg/day), the male control non-diabetes-prone rats showed glucose …