The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for
both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA …

The RNA exosome is a highly conserved ribonuclease endowed with 3′–5′ exonuclease
and endonuclease activities. The multisubunit complex resides in both the nucleus and the …

The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To
understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we …

The RNA exosome complex processes and degrades a wide range of transcripts, including
ribosomal RNAs (rRNAs). We used cryo–electron microscopy to visualize the yeast nuclear …

RNA quality control relies on co-factors and adaptors to identify and prepare substrates for
degradation by ribonucleases such as the 3′ to 5′ ribonucleolytic RNA exosome. Here …

Immunoglobulin heavy chain (IgH) locus-associated G-rich long noncoding RNA (SμGLT) is
important for physiological and pathological B cell DNA recombination. We demonstrate that …

Endogenous retroviruses (ERVs) are remnants of ancient parasitic infections and comprise
sizable portions of most genomes. Although epigenetic mechanisms silence most ERVs by …

Summary The Ski2-Ski3-Ski8 (Ski238) helicase complex directs cytoplasmic mRNAs toward
the nucleolytic exosome complex for degradation. In yeast, the interaction between Ski238 …

The nuclear RNA exosome is an essential and versatile machinery that regulates maturation
and degradation of a huge plethora of RNA species. The past two decades have witnessed …

The evolutionarily conserved RNA exosome is a multisubunit ribonuclease complex that
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …