Emergence of SARS-CoV-2 omicron lineages BA. 4 and BA. 5 in South Africa

H Tegally, M Moir, J Everatt, M Giovanetti… - Nature medicine, 2022 - nature.com
Abstract Three lineages (BA. 1, BA. 2 and BA. 3) of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa's …

Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

B Pickering, O Lung, F Maguire, P Kruczkiewicz… - Nature …, 2022 - nature.com
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

Zoonosis and zooanthroponosis of emerging respiratory viruses

AM Khalil, L Martinez-Sobrido… - Frontiers in Cellular and …, 2024 - frontiersin.org
Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses.
All human pandemics have been caused by the members of two major virus families …

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

BJ Willett, J Grove, OA MacLean, C Wilkie… - Nature …, 2022 - nature.com
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health
response to COVID-19. The emergence of hypermutated, increasingly transmissible variants …

Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants

AK Reuschl, LG Thorne, MVX Whelan… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …

What can an organ-on-a-chip teach us about human lung pathophysiology?

H Bai, DE Ingber - Physiology, 2022 - journals.physiology.org
The intertwined relationship between structure and function has been key to understanding
human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a …

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

TP Peacock, JC Brown, J Zhou, N Thakur, K Sukhova… - biorxiv, 2022 - biorxiv.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread
across the world. It has been demonstrated that Omicron's high number of Spike mutations …

Continued emergence and evolution of Omicron in South Africa: New BA. 4 and BA. 5 lineages

H Tegally, M Moir, J Everatt, M Giovanetti, C Scheepers… - MedRxiv, 2022 - medrxiv.org
South Africa's fourth COVID-19 wave was driven predominantly by three lineages (BA. 1, BA.
2 and BA. 3) of the SARS-CoV-2 Omicron variant of concern. We have now identified two …

Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

CCS Tan, SD Lam, D Richard, CJ Owen… - Nature …, 2022 - nature.com
Abstract SARS-CoV-2, the causative agent of the COVID-19 pandemic, can infect a wide
range of mammals. Since its spread in humans, secondary host jumps of SARS-CoV-2 from …

Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

X Ou, G Xu, P Li, Y Liu, F Zan, P Liu, J Hu, X Lu… - Cell Discovery, 2023 - nature.com
The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related …