Primary liver cancer (PLC), which includes hepatocellular carcinoma (HCC) and intrahepatic
cholangiocarcinoma (iCCA), remains a leading cause of cancer-related death worldwide …

Pancreatic adenocarcinoma (PDAC) is considered an immunologically 'cold'tumor that fails
to attract or support effector T cells. Most PDACs are resistant to immune checkpoint …

Background Approximately half of all human cancers harbour mutations in the p53 gene,
leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with a poor overall
survival rate. Cellular stress response pathways promoting cancer cell fitness in harsh tumor …

Pancreatic cancer, characterized by its insidious onset, high invasiveness, resistance to
chemotherapy, and a grim prognosis, with a five-year survival rate hovering below 10%. The …

In recent years, it has been shown that stroma compartment can favor tumor proliferation
and aggressiveness. Although extensive research with network analyses such as Weighted …

Despite many decades of research, pancreatic ductal adenocarcinoma (PDAC) remains one
of the most difficult cancers to diagnose and treat effectively. Although there have been …

Cancer has long been believed to be a genetic disease caused by the accumulation of
mutations in key genes involved in cellular processes. However, recent advances in …

Genetic mutations arising from various internal and external factors drive cells to become
cancerous. Cancerous cells undergo numerous changes, including metabolic …

Pancreatic diseases pose considerable health challenges due to their complex etiology and
limited therapeutic options. Mitochondrial uncoupling protein 2 (UCP2), highly expressed in …