PIWI-interacting RNA: its biogenesis and functions
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …
PIWI-interacting small RNAs: the vanguard of genome defence
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The …
Biogenesis of small RNAs in animals
VN Kim, J Han, MC Siomi - Nature reviews Molecular cell biology, 2009 - nature.com
Small RNAs of 20–30 nucleotides can target both chromatin and transcripts, and thereby
keep both the genome and the transcriptome under extensive surveillance. Recent progress …
keep both the genome and the transcriptome under extensive surveillance. Recent progress …
A germline-specific class of small RNAs binds mammalian Piwi proteins
Abstract Small RNAs associate with Argonaute proteins and serve as sequence-specific
guides to regulate messenger RNA stability, protein synthesis, chromatin organization and …
guides to regulate messenger RNA stability, protein synthesis, chromatin organization and …
α-Synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
Alpha-synuclein (αSyn) misfolding is associated with several devastating
neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in …
neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in …
A distinct small RNA pathway silences selfish genetic elements in the germline
In the Drosophila germline, repeat-associated small interfering RNAs (rasiRNAs) ensure
genomic stability by silencing endogenous selfish genetic elements such as …
genomic stability by silencing endogenous selfish genetic elements such as …
DNA transposons: nature and applications in genomics
M Muñoz-López, JL García-Pérez - Current genomics, 2010 - ingentaconnect.com
Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …
repetitive elements are able to move within the genome (transposons and retrotransposons) …
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
MA Carmell, A Girard, HJG Van De Kant, D Bourc'his… - Developmental cell, 2007 - cell.com
Summary Small RNAs associate with Argonaute proteins and serve as sequence-specific
guides for regulation of mRNA stability, productive translation, chromatin organization, and …
guides for regulation of mRNA stability, productive translation, chromatin organization, and …
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
LS Gunawardane, K Saito, KM Nishida, K Miyoshi… - science, 2007 - science.org
In Drosophila, repeat-associated small interfering RNAs (rasiRNAs) are produced in the
germ line by a Dicer-independent pathway and function through the PIWI subfamily of …
germ line by a Dicer-independent pathway and function through the PIWI subfamily of …
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes
Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …
suppress transposons and enable gamete maturation. Mammalian transposon-silencing …