Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations

M Fields, A Marcuzzi, A Gonelli, C Celeghini… - International journal of …, 2023 - mdpi.com
Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by
progressive loss of neuronal functions and structures. Despite having different genetic …

TPP-based conjugates: potential targeting ligands

S Batheja, S Gupta, KK Tejavath, U Gupta - Drug Discovery Today, 2024 - Elsevier
Highlights•In this review, the pivotal role of triphenylphosphonium (TPP) and its conjugates
have been widely explored.•The mechanistic insights of TPP-based conjugates endowing …

Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target

YN Yang, MQ Zhang, FL Yu, B Han, MY Bao… - Biochemical …, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

[HTML][HTML] Huntington's disease drug development: a phase 3 pipeline analysis

HJ Van de Roovaart, N Nguyen, TD Veenstra - Pharmaceuticals, 2023 - mdpi.com
Huntington's Disease (HD) is a severely debilitating neurodegenerative disorder in which
sufferers exhibit different combinations of movement disorders, dementia, and behavioral or …

Mitochondrial involvement in sarcopenia

C Affourtit, JE Carré - Acta Physiologica, 2024 - Wiley Online Library
Sarcopenia lowers the quality‐of‐life for millions of people across the world, as accelerated
loss of skeletal muscle mass and function contributes to both age‐and disease‐related …

Targeting mitochondria with small molecules: A promising strategy for combating Parkinson's disease

C Pal - Mitochondrion, 2024 - Elsevier
Abstract Parkinson's disease (PD), a neurodegenerative disorder, is one of the most
significant challenges confronting modern societies, affecting millions of patients globally …

Bibliometric analysis of research on Alzheimer's disease and non-coding RNAs: opportunities and challenges

X Fei, S Wang, J Li, Q Zeng, Y Gao… - Frontiers in Aging …, 2022 - frontiersin.org
Background Non-coding RNAs (ncRNA) are a kind of RNA that does not encode protein,
which play an important role in Alzheimer's disease (AD). However, there is a lack of …

The role of exercise in Parkinson's Disease

MA Almikhlafi - Neurosciences Journal, 2023 - nsj.org.sa
Parkinson's disease (PD) is a progressive widespread neurodegenerative disorder affecting
the brain. It is characterized by dopaminergic neuron degeneration in the substantia nigra …

[HTML][HTML] Flavonoid–phenolic acid hybrids are potent inhibitors of ferroptosis via attenuation of mitochondrial impairment

M Günther, S Dabare, J Fuchs, S Gunesch, J Hofmann… - Antioxidants, 2023 - mdpi.com
Cinnamic acid, ferulic acid, and the flavonoids quercetin and taxifolin (dihydroquercetin) are
naturally occurring compounds found in plants. They are often referred to as polyphenols …

Cobalt nanoparticles induce mitochondrial damage and β-amyloid toxicity via the generation of reactive oxygen species

J Chen, C Chen, N Wang, C Wang, Z Gong, J Du, H Lai… - Neurotoxicology, 2023 - Elsevier
Exposure to cobalt nanoparticles (CoNPs) has been associated with neurodegenerative
disorders, while the mitochondrial-associated mechanisms that mediate their neurotoxicity …