The population genetics of pathogenic Escherichia coli
Escherichia coli is a commensal of the vertebrate gut that is increasingly involved in various
intestinal and extra-intestinal infections as an opportunistic pathogen. Numerous pathotypes …
intestinal and extra-intestinal infections as an opportunistic pathogen. Numerous pathotypes …
A new era in functional genomics screens
L Przybyla, LA Gilbert - Nature Reviews Genetics, 2022 - nature.com
The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …
human genome and then a detailed catalogue of human genome variation associated with …
Map** the energetic and allosteric landscapes of protein binding domains
Allosteric communication between distant sites in proteins is central to biological regulation
but still poorly characterized, limiting understanding, engineering and drug development …
but still poorly characterized, limiting understanding, engineering and drug development …
Ongoing global and regional adaptive evolution of SARS-CoV-2
Understanding the trends in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) evolution is paramount to control the COVID-19 pandemic. We analyzed more than …
2) evolution is paramount to control the COVID-19 pandemic. We analyzed more than …
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
How cellular and organismal complexity emerges from combinatorial expression of genes is
a central question in biology. High-content phenoty** approaches such as Perturb-seq …
a central question in biology. High-content phenoty** approaches such as Perturb-seq …
Epistasis and adaptation on fitness landscapes
C Bank - Annual Review of Ecology, Evolution, and Systematics, 2022 - annualreviews.org
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
The simplicity of protein sequence-function relationships
How complex are the rules by which a protein's sequence determines its function? High-
order epistatic interactions among residues are thought to be pervasive, suggesting an …
order epistatic interactions among residues are thought to be pervasive, suggesting an …
The ecology of hybrid incompatibilities
Ecologically mediated selection against hybrids, caused by hybrid phenotypes fitting poorly
into available niches, is typically viewed as distinct from selection caused by epistatic …
into available niches, is typically viewed as distinct from selection caused by epistatic …
Genetic modifiers and rare Mendelian disease
Despite advances in high-throughput sequencing that have revolutionized the discovery of
gene defects in rare Mendelian diseases, there are still gaps in translating individual …
gene defects in rare Mendelian diseases, there are still gaps in translating individual …
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among
these, several solute carrier proteins (SLCs), representing the largest group of transporters …
these, several solute carrier proteins (SLCs), representing the largest group of transporters …