Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

Circular RNA in cancer

VM Conn, AM Chinnaiyan, SJ Conn - Nature Reviews Cancer, 2024 - nature.com
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer

X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …

Biogenesis and functions of circular RNAs come into focus

MS **ao, Y Ai, JE Wilusz - Trends in cell biology, 2020 - cell.com
Many eukaryotic protein-coding genes are able to generate exonic circular RNAs. Most of
these covalently linked transcripts are expressed at low levels, but some accumulate to …

Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”

K Grillone, C Riillo, F Scionti, R Rocca… - Journal of Experimental …, 2020 - Springer
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …

Role of circular RNAs in brain development and CNS diseases

SL Mehta, RJ Dempsey, R Vemuganti - Progress in neurobiology, 2020 - Elsevier
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Y Liu, G Qiu, Y Luo, S Li, Y Xu, Y Zhang, J Hu… - … & Molecular Medicine, 2022 - nature.com
As the most prevalent bone tumor in children and adolescents, the pathogenesis and
metastasis of osteosarcoma (OS) remain largely unclear. Here, we investigated the …

[HTML][HTML] Selected in situ hybridization methods: principles and application

D Veselinyová, J Mašlanková, K Kalinová, H Mičková… - Molecules, 2021 - mdpi.com
We are experiencing rapid progress in all types of imaging techniques used in the detection
of various numbers and types of mutation. In situ hybridization (ISH) is the primary technique …

New progresses of circular RNA biology: from nuclear export to degradation

M Zhou, MS **ao, Z Li, C Huang - RNA biology, 2021 - Taylor & Francis
Circular RNA, typically generated from backsplicing reaction, is a class of single-stranded
and covalently linked RNA. Although most circular RNAs are lowly expressed, some of them …

Imaging and quantification of human and viral circular RNAs<? mode longmeta?>

DK Jaijyan, S Yang, S Ramasamy, A Gu… - Nucleic Acids …, 2024 - academic.oup.com
We present a robust approach for cellular detection, imaging, localization, and quantification
of human and viral encoded circular RNAs (circRNA) using amplified fluorescence in situ …