Assessing and mitigating batch effects in large-scale omics studies
Y Yu, Y Mai, Y Zheng, L Shi - Genome Biology, 2024 - Springer
Batch effects in omics data are notoriously common technical variations unrelated to study
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …
Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
Y Yu, W Hou, Y Liu, H Wang, L Dong, Y Mai… - Nature …, 2024 - nature.com
Certified RNA reference materials are indispensable for assessing the reliability of RNA
sequencing to detect intrinsically small biological differences in clinical settings, such as …
sequencing to detect intrinsically small biological differences in clinical settings, such as …
Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: the paradigm of radiotherapy
Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …
survivors may suffer from adverse events either at the time of therapy or later in life …
Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method
Background Batch effects are notoriously common technical variations in multiomics data
and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch …
and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch …
A real-world multi-center RNA-seq benchmarking study using the Quartet and MAQC reference materials
Translating RNA-seq into clinical diagnostics requires ensuring the reliability and cross-
laboratory consistency of detecting clinically relevant subtle differential expressions, such as …
laboratory consistency of detecting clinically relevant subtle differential expressions, such as …
Multi-OMICS approaches in cancer biology: New era in cancer therapy
S Chakraborty, G Sharma, S Karmakar… - Biochimica et Biophysica …, 2024 - Elsevier
Innovative multi-omics frameworks integrate diverse datasets from the same patients to
enhance our understanding of the molecular and clinical aspects of cancers. Advanced …
enhance our understanding of the molecular and clinical aspects of cancers. Advanced …
Quartet DNA reference materials and datasets for comprehensively evaluating germline variant calling performance
Background Genomic DNA reference materials are widely recognized as essential for
ensuring data quality in omics research. However, relying solely on reference datasets to …
ensuring data quality in omics research. However, relying solely on reference datasets to …
The Quartet Data Portal: integration of community-wide resources for multiomics quality control
Abstract The Quartet Data Portal facilitates community access to well-characterized
reference materials, reference datasets, and related resources established based on a …
reference materials, reference datasets, and related resources established based on a …
Exposome-wide ranking to uncover environmental chemicals associated with dyslipidemia: a panel study in healthy older Chinese adults from the BAPE study
Background: Environmental contaminants (ECs) are increasingly recognized as crucial
drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact …
drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact …
A review of artificial intelligence based biological-tree construction: priorities, methods, applications and trends
Biological tree analysis serves as a pivotal tool in uncovering the evolutionary and
differentiation relationships among organisms, genes, and cells. Its applications span …
differentiation relationships among organisms, genes, and cells. Its applications span …