HIV-1: fifteen proteins and an RNA
AD Frankel, JAT Young - Annual review of biochemistry, 1998 - annualreviews.org
Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins.
Substantial progress has been made toward understanding the function of each protein, and …
Substantial progress has been made toward understanding the function of each protein, and …
G-quadruplexes in viruses: function and potential therapeutic applications
M Métifiot, S Amrane, S Litvak… - Nucleic acids …, 2014 - academic.oup.com
G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four
guanines fold in a planar arrangement through Hoogsteen hydrogen bonds. Although many …
guanines fold in a planar arrangement through Hoogsteen hydrogen bonds. Although many …
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
We describe the construction of a safe, replication-defective and efficient lentiviral vector
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a …
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a …
[HTML][HTML] Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development
Asymmetric localization of oskar ribonucleoprotein (RNP) granules to the oocyte posterior is
crucial for abdominal patterning and germline formation in the Drosophila embryo. We show …
crucial for abdominal patterning and germline formation in the Drosophila embryo. We show …
An architectural role of specific RNA–RNA interactions in oskar granules
Ribonucleoprotein (RNP) granules are membraneless condensates that organize the
intracellular space by compartmentalization of specific RNAs and proteins. Studies have …
intracellular space by compartmentalization of specific RNAs and proteins. Studies have …
RNA structure: advances and assessment of 3D structure prediction
Biological functions of RNA molecules are dependent upon sustained specific three-
dimensional (3D) structures of RNA, with or without the help of proteins. Understanding of …
dimensional (3D) structures of RNA, with or without the help of proteins. Understanding of …
Structural determinants and mechanism of HIV-1 genome packaging
K Lu, X Heng, MF Summers - Journal of molecular biology, 2011 - Elsevier
Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …
Potent effect of target structure on microRNA function
MicroRNAs (miRNAs) are small noncoding RNAs that repress protein synthesis by binding
to target messenger RNAs. We investigated the effect of target secondary structure on the …
to target messenger RNAs. We investigated the effect of target secondary structure on the …
How retroviruses select their genomes
V D'Souza, MF Summers - Nature Reviews Microbiology, 2005 - nature.com
As retroviruses assemble in infected cells, two copies of their full-length, unspliced RNA
genomes are selected for packaging from a cellular milieu that contains a substantial excess …
genomes are selected for packaging from a cellular milieu that contains a substantial excess …
Dimerization of retroviral RNA genomes: an inseparable pair
Many viruses carry more than one segment of nucleic acid into the virion particle, but
retroviruses are the only known group of viruses that contain two identical (or nearly …
retroviruses are the only known group of viruses that contain two identical (or nearly …