Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Parahydrogen‐based hyperpolarization for biomedicine

JB Hövener, AN Pravdivtsev, B Kidd… - Angewandte Chemie …, 2018 - Wiley Online Library
Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange

AB Schmidt, H de Maissin, I Adelabu, S Nantogma… - ACS …, 2022 - ACS Publications
Despite great successes in oncology, patient outcomes are often still discouraging, and
hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of …

15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH

ML Truong, T Theis, AM Coffey… - The journal of …, 2015 - ACS Publications
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization
technique that enables nuclear spin polarization enhancement of molecules via concurrent …

Quantitative NMR-based biomedical metabolomics: Current status and applications

AA Crook, R Powers - Molecules, 2020 - mdpi.com
Nuclear Magnetic Resonance (NMR) spectroscopy is a quantitative analytical tool
commonly utilized for metabolomics analysis. Quantitative NMR (qNMR) is a field of NMR …

Quantum sensing for energy applications: Review and perspective

SE Crawford, RA Shugayev, HP Paudel… - Advanced Quantum …, 2021 - Wiley Online Library
On its revolutionary threshold, quantum sensing is creating potentially transformative
opportunities to exploit intricate quantum mechanical phenomena in new ways to make …

Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]-Pyruvate

P TomHon, M Abdulmojeed, I Adelabu… - Journal of the …, 2021 - ACS Publications
Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …

Hyperpolarized water as universal sensitivity booster in biomolecular NMR

C Hilty, D Kurzbach, L Frydman - Nature protocols, 2022 - nature.com
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

The 13C hyperpolarized pyruvate generated by ParaHydrogen detects the response of the heart to altered metabolism in real time

E Cavallari, C Carrera, M Sorge, G Bonne, A Muchir… - Scientific reports, 2018 - nature.com
Many imaging methods have been proposed to act as surrogate markers of organ damage,
yet for many candidates the essential biomarkers characteristics of the injured organ have …