The role of computational tools in drug discovery and development is becoming increasingly
important due to the rapid development of computing power and advancements in …

Tuberculosis (TB) is a leading cause of mortality and morbidity with an estimated 1.7 billion
people latently infected with the pathogen worldwide. Clinically, TB infection presents itself …

Resveratrol (RSV) is known to possess anticancer properties in many types of cancers like
breast cancer, in which POLD1 may serve as a potential target. However, the anticancer …

Biofilm formation mediated by sortase A (srtA) is important for bacterial colonisation and
resistance to antibiotics. Thus, the inhibitor of SrtA may represent a promising agent for …

COVID-19 is a devastating respiratory and inflammatory illness caused by a new
coronavirus that is rapidly spreading throughout the human population. Over the past 12 …

Background Enteric fever caused by Salmonella enterica serovar typhi and Salmonella
enterica serovar paratyphi A remains one of the most common causes of community …

Through the approach of molecular hybridization, this study rationally designed and
synthesized new trifluoromethyl-1, 3, 4-oxadiazole amide derivatives, denoted as 1a–1n …

In the present study, we aim to identify a potential drug candidate that targets the
Monocarboxylate Transporter-4 (MCT-4) protein. Syrosingopine (SRY) is a well-established …

Background: This study aims to identify the essential cell cycle-related genes associated
with prognosis in breast cancer (BRCA), and to verify the relationship between the central …

Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the
pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for …