Neutrophils are polymorphonuclear leukocytes of the phagocytic system that act as first line
of host defense against invading pathogens but are also important mediators of …

Myeloid cells are crucial effectors of the innate immune response and important regulators of
adaptive immunity. The differentiation and activation of myeloid cells requires the timely …

Background Intra-sample cellular heterogeneity presents numerous challenges to the
identification of biomarkers in large Epigenome-Wide Association Studies (EWAS). While a …

Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …

Abstract The European Genome-phenome Archive (EGA) is a permanent archive that
promotes the distribution and sharing of genetic and phenotypic data consented for specific …

An outstanding challenge of epigenome-wide association studies (EWASs) performed in
complex tissues is the identification of the specific cell type (s) responsible for the observed …

Aim: An outstanding challenge in epigenome studies is the estimation of cell-type
proportions in complex epithelial tissues. Materials & methods: Here, we construct and …

Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …

Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …