Novel agents for the pharmacological treatment of alcohol use disorder

EM Burnette, SJ Nieto, EN Grodin, LR Meredith… - Drugs, 2022 - Springer
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Psychedelic therapy in the treatment of addiction: the past, present and future

R Zafar, M Siegel, R Harding, T Barba… - Frontiers in …, 2023 - frontiersin.org
Psychedelic therapy has witnessed a resurgence in interest in the last decade from the
scientific and medical communities with evidence now building for its safety and efficacy in …

Family health behaviors

I Fadlon, TH Nielsen - American Economic Review, 2019 - aeaweb.org
We study how health behaviors are shaped through family spillovers. We leverage
administrative data to identify the effects of health shocks on family members' consumption …

[HTML][HTML] FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit

KH Flippo, SAJ Trammell, MP Gillum, I Aklan, MB Perez… - Cell metabolism, 2022 - cell.com
Excessive alcohol consumption is a major health and social issue in our society.
Pharmacologic administration of the endocrine hormone fibroblast growth factor 21 (FGF21) …

Immune treatments for alcohol use disorder: A translational framework

LR Meredith, EM Burnette, EN Grodin, MR Irwin… - Brain, behavior, and …, 2021 - Elsevier
While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Alcohol metabolism in alcohol use disorder: a potential therapeutic target

T Lehner, B Gao, B Mackowiak - Alcohol and Alcoholism, 2024 - academic.oup.com
Ethanol metabolism plays an essential role in how the body perceives and experiences
alcohol consumption, and evidence suggests that modulation of ethanol metabolism can …

[HTML][HTML] FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at …

S Søberg, ES Andersen, NB Dalsgaard, I Jarlhelt… - Molecular …, 2018 - Elsevier
Objective Excessive alcohol consumption is a leading cause of global morbidity and
mortality. However, knowledge of the biological factors that influence ad libitum alcohol …

Anticraving therapy for alcohol use disorder: A clinical review

WW Shen - Neuropsychopharmacology reports, 2018 - Wiley Online Library
Aim In this review, the author focused on anticraving therapy for alcohol use disorder (AUD)
defined by DMS‐5. A comprehensive review was carried out on the available published …

Current therapeutic options and potential of mesenchymal stem cell therapy for alcoholic liver disease

J Han, C Lee, J Hur, Y Jung - Cells, 2022 - mdpi.com
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic
or binge consumption of alcohol. The therapeutic efficiency of current therapies for ALD is …

Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study

MF Ho, C Zhang, I Moon, M Tuncturk… - Translational …, 2024 - nature.com
Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide.
Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy …