Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …

Abstract Interleukin‐6 (IL‐6), a pleiotropic cytokine, plays a pivotal role in the
pathophysiology of various diseases including diabetes, atherosclerosis, Alzheimer's …

Schizophyllum commune, a fleshy fungus, is an important medicinal and food-homologous
mushroom in China. In this work, eight undescribed sesquiterpenes schizomycins A–H (1–8) …

ABSTRACT gp130 functions as a shared signal-transducing subunit not only for interleukin
(IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling …

The epidermal growth factor receptor (EGFR) is vital for regulating cellular functions,
including cell division, migration, survival, apoptosis, angiogenesis, and cancer. EGFR …

In the current study, we utilized molecular modeling and simulation approaches to define
putative potential molecular targets for Burdock Inulin, including inflammatory proteins such …

Background Rheumatoid arthritis (RA) and osteoporosis (OP) are considered to be complex
diseases. In recent studies, a positive association between RA and OP has been reported …

Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …

This review discusses novel therapeutic receptors being explored agonistically or
antagonistically to develop alternative treatment options for allergic conjunctivitis. These …

A large scale of pandemic coronavirus disease (COVID-19) in the past five years motivates a
great deal of endeavors donating to the exploration on therapeutic drugs against COVID-19 …